More tidbits are coming out from that exhaustive Peter Cuneo interview, including the news that Sony has renewed their rights to Spider-Man, and a "most-likely" release date for Spider-Man 4.
"As far as Spider-Man 4, it's really up to Sony and it up to them, most likely scenario is 2010 or 2011 but we can't speak for them and I think that we don't know. They have given us their re-up payment for that film so you know they're going to make it within a reasonable timeframe. Sony may be looking at some issues with the cast and so on, I think they have to make some decisions."
Speculators say that Cuneo's language suggests that it all hinges on casting. There is still no confirmation that Sam Raimi will return to direct, and the original cast is up in the air as well since they were only under contract for three films. Needless to say, losing Kirsten Dunst wouldn't be a bad thing, but it remains to be seen if the franchise can continue with a more massive re-cast.